Phoenix Fan Fusion (formerly Phoenix Comicon and Phoenix Comic Fest) is a speculative fiction entertainment and comic book convention held annually in Phoenix, Arizona. It was founded as the Phoenix Cactus Comicon in June 2002, and originally consisted of a one-day six-hour event held in Ahwatukee, Arizona. The convention plays host to comic related panels, programming events, art contests, and autograph signings for all ages. It is a four-day event (Thursday-Sunday) held during the summer at the Phoenix Convention Center in downtown Phoenix. On Thursday evening prior to the official opening of the event, there is a preview for professionals, exhibitors, and select guests pre-registered for all four days.

Originally showcasing comic books, science fiction/fantasy and film/television, and related popular arts, the convention has expanded over the years to include a larger range of pop culture elements, such as horror, anime, manga, animation, toys, collectible card games, video games, webcomics, and fantasy novels. In 2016, the convention set an attendance record of 106,096, and reportedly generates approximately $5 million in revenue for the city of Phoenix. Then-Phoenix Comicon also began to expand programming into the surrounding hotels starting in 2013, including the Hyatt Regency, Marriott Renaissance and Sheraton Phoenix Downtown Hotels.